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An initial Chinese trial involving 24 patients with severe disorders of consciousness found signs of improved awareness in 13 after deep brain regions—particularly the thalamus—were stimulated with focused ultrasound delivered through the skull, without surgery. However, the results do not prove that the technique alone caused the improvement, the trial details have not been published in a peer-reviewed study, and improvement does not mean a full return of consciousness. The researchers say that assessing the treatment’s effectiveness and safety will require larger trials comparing stimulation with standard care and following patients for longer.
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