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A legal analysis published in *Science* concluded that products marketed to slow aging and extend lifespan often meet the definition of drugs under U.S. law—even if aging is not considered a disease—and that selling them as supplements or for research purposes does not exempt them from regulation. These products include metformin, rapamycin, compounds that serve as precursors to NAD+, and resveratrol. The U.S. Food and Drug Administration has not approved any of them to combat aging, and approval for other medical uses does not establish that they are effective for this purpose. Scientifically, proving that a product extends lifespan or improves healthspan requires long-term studies, and there is no consensus on surrogate markers that can demonstrate such effects. The researchers therefore called for reliable evidence and oversight to protect consumers from unsubstantiated claims.
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