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A U.S. trial involving 830 children under the age of six found that a 38% silver diamine fluoride solution stopped tooth decay from progressing in 54% of affected sites after six months, compared with 22.5% in the group given a placebo solution. After the solution was reapplied, the rates at month eight were 50.2% and 17.4%, respectively. The liquid is applied directly to the tooth without drilling or anesthetic injections, but it does not rebuild lost tissue or always eliminate the need for fillings or other treatments, and it may turn the treated decayed area black. The findings support its use to control tooth decay in some children, but follow-up lasted only eight months, and its use for this purpose is not officially approved in the United States, making assessment and follow-up by a dentist essential.
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