Immune system changes at 40 and 60

A recent study reveals that aging of the immune system does not occur as a continuous, gradual process, but instead passes through two main phases of change: the first around the age of 40, and the second after age 60. The study, which analyzed 3.8 million immune cells from 1,828 individuals aged between 19 and 97 years, showed that changes in "CD4 T" cells become prominent near age 40, playing a role in regulating immune response. In contrast, "CD8 T" cells change after age 60, aiding in the detection and elimination of infected or abnormal cells. The findings indicate that cell functions decline with age, accompanied by an increase in inflammatory markers. Additionally, changes in the immune system may occur at different stages in life between men and women, although not all individuals follow the same patterns. The study's results contribute to understanding why susceptibility to diseases increases with age and help identify optimal periods for preventive interventions.

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