Repeated IVF Failures: Causes and Outlook

The article reviews the causes and challenges of repeated IVF failures, explaining that a successful pregnancy depends on a complex interplay between embryo quality, uterine readiness, hormonal factors, and immune responses. One of the main potential reasons for repeated failure is the presence of chromosomal abnormalities in the embryos that are not visible, especially as maternal age advances. Additionally, uterine issues such as fibroids and adhesions, as well as hormonal disorders like thyroid problems and elevated prolactin levels, can contribute to failure. Experts recommend a comprehensive evaluation that includes hormone tests, uterine assessment, and genetic screening before initiating new cycles. The focus is also on enhancing embryo quality through pre-transfer genetic testing, aiming to improve the chances of success in IVF treatments.

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